(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

Base Information

Chemical Name:(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate
CAS No.:420133-88-6
Molecular Formula:C₁₃H₂₁NS₃
Molecular Weight:287.514
Hs Code.:

Synonyms:(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

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Chemical Property of (R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

Chemical Property:

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Technology Process of (R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

There total 3 articles about (R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 75-15-0,12122-00-8
carbon disulfide

: 420134-19-6
(R)-2-cyclohexyl-4-ethyl-2-thiazoline

: 74-88-4
methyl iodide

: 420133-88-6
(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

Guidance literature:: (R)-2-cyclohexyl-4-ethyl-2-thiazoline; With tert.-butyl lithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 3h;

carbon disulfide; In tetrahydrofuran; at -40 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0957-4166(01)00481-5

Reference yield:

: 5874-05-5
methyl cyclohexanecarbodithionate

: 420133-88-6
(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / Et₃N / 48 h / 20 °C

2.1: 98 percent / mesylchloride; Et₃N / tetrahydrofuran / 0.17 h / 20 °C

3.1: t-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C

3.2: tetrahydrofuran / 2 h / -40 °C

3.3: 82 percent / tetrahydrofuran / 20 °C

With tert.-butyl lithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; cyclohexane;
DOI:10.1016/S0957-4166(01)00481-5

Reference yield:

: 420133-81-9
(R)-N-[1-(hydroxymethyl)propyl]cyclohexanethiocarboxamide

: 420133-88-6
(R)-methyl-1-(4-ethyl-4,5-dihydro-2-thiazolyl)cyclohexanedithiocarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / mesylchloride; Et₃N / tetrahydrofuran / 0.17 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C

2.2: tetrahydrofuran / 2 h / -40 °C

2.3: 82 percent / tetrahydrofuran / 20 °C

With tert.-butyl lithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; cyclohexane;
DOI:10.1016/S0957-4166(01)00481-5