2-Bromo-5-formyl-3-methylpyridine

Base Information

• Chemical Name: 2-Bromo-5-formyl-3-methylpyridine
• CAS No.: 885167-81-7
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.035
• Mol file: 885167-81-7.mol

Synonyms:6-bromo-5-methylpyridine-3-carbaldehyde

Chemical Property of 2-Bromo-5-formyl-3-methylpyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 300.2±42.0 °C(Predicted)
• PKA: -0.72±0.20(Predicted)
• Density: 1.577±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-5-methylnicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-formyl-3-methylpyridine

There total 2 articles about 2-Bromo-5-formyl-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-morpholinecarboxaldehyde (4394-85-8) + 2,5-dibromo-3-methylpyridine (3430-18-0,141315-43-7) → 6-bromo-5-methylpyridine-3-carbaldehyde (885167-81-7)

Guidance literature:

2,5-dibromo-3-methylpyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 25 ℃; for 3h;

4-morpholinecarboxaldehyde; In tetrahydrofuran; at 17 - 25 ℃; for 1h;

Reference yield: 59.0%

→ 6-bromo-5-methylpyridine-3-carbaldehyde (885167-81-7)

Guidance literature:

Reference yield: 75.0%

N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (617703-01-2) + 6-bromo-5-methylpyridine-3-carbaldehyde (885167-81-7) → tert-butyl (2-{[4-(5-formyl-3-methylpyridin-2-yl)benzoyl]amino}phenyl)carbamate (901300-03-6)

Guidance literature:

With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 17 - 60 ℃; for 2h;

upstream raw materials:

4-morpholinecarboxaldehyde

2,5-dibromo-3-methylpyridine

Downstream raw materials:

4-(5-formyl-3-methyl-pyridin-2-yloxy)-benzoic acid methyl ester

tert-butyl (2-{[4-(5-formyl-3-methylpyridin-2-yl)benzoyl]amino}phenyl)carbamate

Methyl 6-bromo-5-methylpyridine-3-carboxylate

tert-butyl (RS)-2-(6-(diphenylmethyleneamino)-5-methylpyridin-3-yl)morpholine-4-carboxylate

Refernces

• 1、 -. "GLYCINE COMPOUND". Page/Page column 24. . Retrieved 2012/07/28.
• 2、 -. "CHEMOKINE RECEPTOR BINDING COMPOUNDS". Page/Page column 51-52. . Retrieved 2010/11/26.