Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

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Chemical Name:Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate
CAS No.:1428261-06-6
Molecular Formula:C₂₂H₂₈N₂O₉
Molecular Weight:464.472
Hs Code.:

Synonyms:Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

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Chemical Property of Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

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Technology Process of Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

There total 4 articles about Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1260897-73-1
ethyl 3-(methoxy(methyl)amino)-3-oxopropanoate

: 1428261-04-4
(S)-N-Benzyloxycarbonyl-4-(2-oxobut-3-en-1-yl)oxazolidin-5-one

: 1428261-06-6
Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

Guidance literature:: With caesium carbonate; In dichloromethane; for 1h; Reflux;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 1428261-06-6
Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 20 °C

3: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

4: caesium carbonate / dichloromethane / 1 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); caesium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 1428261-06-6
Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 20 °C

2: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

3: caesium carbonate / dichloromethane / 1 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130