(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Base Information

Chemical Name:(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate
CAS No.:1428261-08-8
Molecular Formula:C₂₃H₃₃N₃O₁₁S
Molecular Weight:559.595
Hs Code.:

Synonyms:(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Suppliers and Price of (2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

There total 8 articles about (2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1428261-07-7
(2S)-8-ethyl N-(benzyloxycarbonyl)-1-methyl-2-(hydroxyimino)-7-(2-ethoxypropanoyl)-4-oxooctanedioate

: 124-63-0
methanesulfonyl chloride

: 1428261-08-8
(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1428261-06-6
Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

: 1428261-08-8
(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / methanol / 0.17 h / Reflux

2: thionyl chloride / 20 °C

3: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / Reflux

4: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; thionyl chloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 1428261-08-8
(2S)-8-Ethyl N-(benzyloxycarbonyl) 1-methyl-2-(methylsulfonyloxyimino)-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: Multi-step reaction with 8 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 20 °C

3: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

4: caesium carbonate / dichloromethane / 1 h / Reflux

5: sodium hydrogencarbonate / methanol / 0.17 h / Reflux

6: thionyl chloride / 20 °C

7: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / Reflux

8: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; thionyl chloride; oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydroxylamine hydrochloride; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130