(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

Base Information

Chemical Name:(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate
CAS No.:1428260-98-3
Molecular Formula:C₂₂H₃₀N₂O₉
Molecular Weight:466.488
Hs Code.:

Synonyms:(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

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Technology Process of (2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

There total 6 articles about (2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₂₁H₂₈N₂O₉

: 1428260-98-3
(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: With thionyl chloride; at 20 ℃;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1428261-06-6
Ethyl N-(benzyloxycarbonyl)2-(methoxy(methyl)carbamoyl)-5-oxo-6-((S)-5-oxooxazolidin-4-yl)hexanoate

: 1428260-98-3
(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol / 0.17 h / Reflux

2: thionyl chloride / 20 °C

With thionyl chloride; sodium hydrogencarbonate; In methanol;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 1428260-98-3
(2S)-8-ethyl N-(benzyloxycarbonyl) 1-methyl-2-amino-7-(2-methoxypropanoyl)-4-oxooctanedioate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 20 °C

2: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

3: caesium carbonate / dichloromethane / 1 h / Reflux

4: sodium hydrogencarbonate / methanol / 0.17 h / Reflux

5: thionyl chloride / 20 °C

With thionyl chloride; oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); sodium hydrogencarbonate; caesium carbonate; N,N-dimethyl-formamide; In methanol; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130