benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate
CAS No.:911210-32-7
Molecular Formula:C₃₈H₄₂N₂O₇
Molecular Weight:638.761
Hs Code.:

Synonyms:benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

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Chemical Property of benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

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Technology Process of benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

There total 14 articles about benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911210-33-8
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

: 911210-32-7
benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1 - 5h;

Reference yield:

: 615568-17-7
6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one

: 911210-32-7
benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium fluoride on basic alumina; potassium iodide / acetonitrile / 72 h / Heating / reflux

2.1: pyridine; thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

4.2: 4 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

6.1: copper diacetate; triethylamine / dichloromethane / 12 - 72 h / 20 °C / Molecular sieve

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 5 h / 20 °C

With pyridine; thionyl chloride; borane-THF; potassium fluoride on basic alumina; tetrabutyl ammonium fluoride; copper diacetate; sodium hydride; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 911210-32-7
benzyl 3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

3.2: 4 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

5.1: copper diacetate; triethylamine / dichloromethane / 12 - 72 h / 20 °C / Molecular sieve

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 5 h / 20 °C

With pyridine; thionyl chloride; borane-THF; tetrabutyl ammonium fluoride; copper diacetate; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;