benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate
CAS No.:911210-33-8
Molecular Formula:C₄₇H₆₂N₂O₇Si
Molecular Weight:795.104
Hs Code.:

benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

Synonyms:benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

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Chemical Property of benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

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Technology Process of benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

There total 14 articles about benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911210-34-9
(3R,4R,5S)-4-(4-hydroxy-phenyl)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester

: 98-80-6
phenylboronic acid

: 911210-33-8
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 12 - 72h; Molecular sieve;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 911210-33-8
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

2.2: 4 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

4.1: copper diacetate; triethylamine / dichloromethane / 12 - 72 h / 20 °C / Molecular sieve

With borane-THF; copper diacetate; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 911210-33-8
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-phenoxy-phenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

3.2: 4 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

5.1: copper diacetate; triethylamine / dichloromethane / 12 - 72 h / 20 °C / Molecular sieve

With pyridine; thionyl chloride; borane-THF; copper diacetate; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;