methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

Base Information

Chemical Name:methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate
CAS No.:1389325-74-9
Molecular Formula:C₂₂H₂₄ClNO₄S
Molecular Weight:433.956
Hs Code.:

Synonyms:methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

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Chemical Property of methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

Chemical Property:

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Technology Process of methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

There total 5 articles about methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-67-3
(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

: 1389325-74-9
methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 0.5h;

Reference yield:

: 1074-86-8
4-formyl indole

: 1389325-74-9
methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 1 h / 20 °C

2.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C

3.2: 4 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389325-74-9
methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)ethyl)-1H-indol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 1 h / 20 °C

2.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C

3.2: 4 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;