(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

Base Information

Chemical Name:(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate
CAS No.:1389326-67-3
Molecular Formula:C₂₂H₂₂ClNO₄S
Molecular Weight:431.94
Hs Code.:

Synonyms:(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

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Technology Process of (E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

There total 4 articles about (E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40137-11-9
diethyl methylsulfonylmethylphosphonate

: 1389327-26-7
methyl 2-(4-chlorophenyl)-2-(4-formyl-1H-indol-1-yl)butanoate

: 1389326-67-3
(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

Guidance literature:: diethyl methylsulfonylmethylphosphonate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 0.0833333h;

methyl 2-(4-chlorophenyl)-2-(4-formyl-1H-indol-1-yl)butanoate; In acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-67-3
(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 1 h / 20 °C

2.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C

3.2: 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1389327-25-6
methyl 2-(4-chlorophenyl)-2-(4-formyl-1H-indol-1-yl)acetate

: 1389326-67-3
(E)-methyl 2-(4-chlorophenyl)-2-(4-(2-(methylsulfonyl)vinyl)-1H-indol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C

2.2: 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;