[N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester

Base Information

• Chemical Name: [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester
• CAS No.: 110209-48-8
• Molecular Formula: C₁₄H₁₇N₃O₆
• Molecular Weight: 323.305
• Mol file: 110209-48-8.mol

Synonyms:[N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester

Chemical Property of [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester

There total 3 articles about [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) → [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester (110209-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 5 h / Heating

2: pyridine / r.t. overnight, then reflux 2 h

3: 1) NaH / 1) DMF, 5 min, 2) DMF, r.t., 18 h

With pyridine; thionyl chloride; sodium hydride;

DOI:10.1002/jhet.5570240221

Reference yield:

2-nitrobenzyl chloride (610-14-0) → [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester (110209-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / r.t. overnight, then reflux 2 h

2: 1) NaH / 1) DMF, 5 min, 2) DMF, r.t., 18 h

With pyridine; sodium hydride;

DOI:10.1002/jhet.5570240221

Reference yield:

2-(o-nitrobenzoyl)-1-acetyl-1-methylhydrazine (59169-42-5) + ethyl bromoacetate (105-36-2) → [N'-Acetyl-N'-methyl-N-(2-nitro-benzoyl)-hydrazino]-acetic acid ethyl ester (110209-48-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMF, 5 min, 2) DMF, r.t., 18 h;

DOI:10.1002/jhet.5570240221

upstream raw materials:

2-(o-nitrobenzoyl)-1-acetyl-1-methylhydrazine

ethyl bromoacetate

ortho-nitrobenzoic acid

2-nitrobenzyl chloride