5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

Base Information

Chemical Name:5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide
CAS No.:1336909-99-9
Molecular Formula:C₂₃H₂₉FN₂O₂
Molecular Weight:384.494
Hs Code.:

Synonyms:5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

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Chemical Property of 5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

Chemical Property:

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Technology Process of 5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

There total 6 articles about 5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 578-22-3
2-methyl-5-hydroxybenzoic acid

: 1336909-99-9
5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / dichloromethane / 0.25 h

2.1: caesium carbonate / copper(l) iodide / 1,4-dioxane / 16.25 h / Reflux

3.1: water; lithium hydroxide / methanol / 16 h / 80 °C

3.2: Acidic aqueous solution

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h

4.2: 64 h

With methanol; water; caesium carbonate; triethylamine; HATU; lithium hydroxide; copper(l) iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 875400-96-7
C-(1-isopropylpiperidin-3-yl)methylamine

: 1353002-01-3
5-(4-fluorophenoxy)-2-methylbenzoic acid

: 1336909-99-9
5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

Guidance literature:: 5-(4-fluorophenoxy)-2-methylbenzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.5h;

C-(1-isopropylpiperidin-3-yl)methylamine; In N,N-dimethyl-formamide; for 64h;

Reference yield:

: 102297-41-6
3-<amino>methyl>pyridine

: 1336909-99-9
5-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / Rh/Al₂O₃ / methanol / 16 h / 50 °C / 30003 Torr

2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h

2.2: pH ~ 14

3.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C

3.2: pH ~ 14

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h

4.2: 64 h

With hydrogen; sodium tris(acetoxy)borohydride; triethylamine; HATU; trifluoroacetic acid; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;