Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate

Base Information

Chemical Name:Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate
CAS No.:80625-19-0
Molecular Formula:C₁₁H₈ClNO₂S
Molecular Weight:253.709
Hs Code.:
DSSTox Substance ID:DTXSID201248354

Synonyms:80625-19-0;methyl 2-chloro-5-phenyl-4-thiazolecarboxylate;Methyl 2-chloro-5-phenylthiazole-4-carboxylate;SCHEMBL9587190;NLGZJNMPLULMIL-UHFFFAOYSA-N;DTXSID201248354;Methyl2-chloro-5-phenylthiazole-4-carboxylate;methyl 5-phenyl-2-chloro-4-thiazolecarboxylate

Suppliers and Price of Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:252.9964274
Heavy Atom Count:16
Complexity:258

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(SC(=N1)Cl)C2=CC=CC=C2

Technology Process of Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate

There total 4 articles about Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 80625-19-0
methyl 5-phenyl-2-chloro-4-thiazolecarboxylate

Guidance literature:

Reference yield: 51.0%

: 80625-18-9
methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate

: 80625-19-0
methyl 5-phenyl-2-chloro-4-thiazolecarboxylate

Guidance literature:: With copper dichloride; isopentyl nitrite; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 100-52-7
benzaldehyde

: 80625-19-0
methyl 5-phenyl-2-chloro-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / -60 - 20 °C / Inert atmosphere

2: acetone / 58 °C

3: copper dichloride; isopentyl nitrite / acetonitrile / 5 h / 20 °C / Inert atmosphere

With potassium tert-butylate; copper dichloride; isopentyl nitrite; In tetrahydrofuran; acetone; acetonitrile;