80625-18-9

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
METHYL 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLATE is used as a chemical intermediate for the synthesis of new drugs. Its unique structural features, including the thiazole ring, amino group, phenyl group, and carboxylate group, make it a versatile building block for the development of pharmaceutical agents with potential therapeutic applications.
Used in Organic Synthesis:
METHYL 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLATE is used as a reagent in organic synthesis for the preparation of various organic compounds. Its functional groups can be utilized in a range of chemical reactions, enabling the synthesis of diverse organic molecules with potential applications in various industries.
Used in Materials Science:
METHYL 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLATE may have potential applications in materials science, where its unique structural features could be employed to develop new materials with specific properties. Further research is needed to explore its capabilities and limitations in this field.
Further research on the properties and potential applications of METHYL 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLATE is warranted to fully understand its capabilities and limitations in these and other fields.

Upstream product

• 93439-36-2 2-Chlor-2,3-epoxy-3-phenyl-propionsaeure-methylester 
• 17356-08-0 thiourea 
• 32803-73-9 methyl 3-phenyl-3-chloro-2-ketopropionate 
• 100-52-7 benzaldehyde 
• 98-80-6 phenylboronic acid 
• 914349-71-6 5-bromo-2-tert-butoxycarbonylamino-thiazole-4-carboxylic acid methyl ester 
• 116-54-1 dichloroacetic acid methyl ester 
• 67-56-1 methanol 
• 535-15-9 ethyl 1,1-dichloroacetate 
• 115174-39-5 2-Amino-5-phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 

Downstream Products

• 99972-45-9 methyl 5-phenylthiazole-4-carboxylate 
• 80625-19-0 methyl 5-phenyl-2-chloro-4-thiazolecarboxylate 
• 802276-49-9 2-amino-5-phenyl-thiazole-4-carboxylic acid 
• 127919-00-0 methyl 2-bromo-5-phenyl-1,3-thiazole-4-carboxylate 
• 737824-35-0 methyl 2-(acetylamino)-5-phenyl-1,3-thiazole-4-carboxylate 
• 13743-14-1 5-phenyl-1,3-thiazole-4-carboxylic acid 
• 127918-95-0 t-butyl [2-(2-chloro-5-phenyl-4-thiazolecarboxamido)ethyl]carbamate 

Relevant academic research and scientific papers

Competition of the Hantzsch and Boese reactions in the interaction of 1-thiocarbamoylthiosemicarbazide and phenylchloropyruvic acid methyl ester

1-Thiocarbamoylthiosemicarbazide, the synthetic equivalent of thiourea and thiosemicarbazide, reacts with phenylchloropyruvic acid methyl ester exclusively as thiourea (Hantzsch reaction) forming 2-hydrazo-4-methoxycarbonyl-5-phenylthiazole. Diacetylation

Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors

A series of 17 compounds (12–16 b) with 2,4,5-trisubstitutedthiazole scaffold having 5-aryl group, 4-carboxylic acid/ester moiety, and 2-amino/amido/ureido functional groups were synthesised, characterised, and evaluated for their carbonic anhydrase (CA)-III inhibitory activities using the size exclusion Hummel–Dreyer method (HDM) of chromatography. Compound 12a with a free amino group at the 2-position, carboxylic acid moiety at the 4-position, and a phenyl ring at the 5-position of the scaffold was found to be the most potent CA-III inhibitor (Ki = 0.5 μM). The presence of a carboxylic acid group at the 4-position of the scaffold was found to be crucial for the CA-III inhibitory activity. Furthermore, replacement of the free amino group with an amide and urea group resulted in a significant reduction of activity (compounds 13c and 14c, Ki = 174.1 and 186.2 μM, respectively). Thus, compound 12a (2-amino-5-phenylthiazole-4-carboxylic acid) can be considered as the lead molecule for further modification and development of more potent CA-III inhibitors.

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF

The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.

Novel Thiazole Carboxylic Acid derivatives possessing a "zinc Binding Feature" as Potential human glyoxalase-I inhibitors

Glyoxalase-I (Glo-I) enzyme is an attractive new target for developing new cancer therapeutics. This enzyme is a dimeric mononuclear zinc coordinating metalloenzyme, and the core zinc ion was utilized in designing potentially active inhibitors possessing

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS

The invention relates to 3-aza-bicyclo[3.3.0]octane derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as orexin receptor antagonists.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as m