tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

Base Information

Chemical Name:tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane
CAS No.:80109-53-1
Molecular Formula:C₂₅H₄₀O₃SSi
Molecular Weight:448.742
Hs Code.:

Synonyms:tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

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Chemical Property of tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

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Technology Process of tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

There total 8 articles about tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 95532-27-7
(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanmethanol

: 80109-53-1
tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 20h;
DOI:10.1021/jo00209a017

Reference yield:

: 2973-86-6
lithium thiophenoxide

: 80109-53-1
tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / dimethylformamide / 3 h / 110 °C

2: diethyl ether / 0 °C

3: LiAlH₄ / diethyl ether / 0 °C

4: 82 percent / diphenyl diselenide, 30percent aq. H₂O₂ / CH₂Cl₂; diethyl ether / 7 h / 25 °C

5: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 25 °C

With dmap; lithium aluminium tetrahydride; diphenyl diselenide; dihydrogen peroxide; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00209a017

Reference yield:

: 95671-28-6
(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylthio)methyl>-4-indancarboxylic acid

: 80109-53-1
tert-butyl<<(1S,3aR,4S,5R,7aS)-1-ethyl-3a,4,5,7a-tetrahydro-5-<(phenylsulfonyl)methyl>-4-indanyl>methoxy>dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0 °C

2: LiAlH₄ / diethyl ether / 0 °C

3: 82 percent / diphenyl diselenide, 30percent aq. H₂O₂ / CH₂Cl₂; diethyl ether / 7 h / 25 °C

4: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 25 °C

With dmap; lithium aluminium tetrahydride; diphenyl diselenide; dihydrogen peroxide; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo00209a017