(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

Base Information

Chemical Name:(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid
CAS No.:648861-62-5
Molecular Formula:C₂₆H₂₂Cl₂N₂O₃
Molecular Weight:481.378
Hs Code.:

Synonyms:(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

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Technology Process of (R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

There total 6 articles about (R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid (S)-1-ethoxycarbonyl-ethyl ester

: 648869-63-0
(S)-3-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid (S)-1-ethoxycarbonyl-ethyl ester

: 649551-06-4
JNJ-17156516

: 648861-62-5
(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 85 ℃; for 4h;

Reference yield:

: 648869-66-3
3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid ethyl ester

: (R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid ethyl ester

: (S)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid ethyl ester

: 649551-06-4
JNJ-17156516

: 648861-62-5
(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

Guidance literature:: With Mucor miehei lipase; In phosphate buffer; isopropyl alcohol; at 20 ℃; for 240h; pH=7; Title compound not separated from byproducts.;
DOI:10.1021/jo071166m

Reference yield:

: 6-(3,4-dichlorophenyl)-6-oxo-2-m-tolylhex-4-ynoic acid (S)-1-ethoxycarbonylethyl ester

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 649551-06-4
JNJ-17156516

: 648861-62-5
(R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid

: C₂₆H₂₂N₂O₃Cl₂

Guidance literature:: 6-(3,4-dichlorophenyl)-6-oxo-2-m-tolylhex-4-ynoic acid (S)-1-ethoxycarbonylethyl ester; 4-methoxyphenylhydrazine hydrochloride; With caesium carbonate; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; acetic acid; at 85 ℃; for 4h; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jo071166m