648869-66-3

Upstream product

• 648869-73-2 3-bromomethyl-5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazole 
• 40061-55-0 ethyl m-methylphenylacetate 
• 648869-65-2 6-(3,4-dichlorophenyl)-6-oxo-2-m-tolylhex-4-ynoic acid ethyl ester 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 126839-66-5 5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 2642-63-9 3',4'-dichloroacetophenone 
• 648869-25-4 [5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl] methanol 

Downstream Products

• 649551-06-4 JNJ-17156516 
• 648861-62-5 (R)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl propionic acid 
• 648869-37-8 3-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-methyl-2-m-tolyl-propionic acid ethyl ester 
• 648869-53-8 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-fluoro-2-m-tolyl-propionic acid ethyl ester 
• 648861-60-3 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid 

Relevant academic research and scientific papers

Design of concise, scalable route to a cholecystokinin 1 (CCK 1) receptor antagonist

(Chemical Equation Presented) Development of efficient, scalable routes for the synthesis of (S)-3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol- 3-yl]-2-m-tolyl propionic acid, a selective cholecystokinin 1 (CCK 1) receptor antagonist, is descri

Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity

High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.