(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Base Information

• Chemical Name: (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid
• CAS No.: 1187451-41-7
• Molecular Formula: C₂₃H₂₂N₆O₄S
• Molecular Weight: 478.531
• Mol file: 1187451-41-7.mol

Synonyms:(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Chemical Property of (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Chemical Property:

• Boiling Point: 769.4±70.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Omidenepag ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Omidenepag, is a novel selective, non-prostanoid EP2 receptor agonist for the treatment of Glaucoma:

Technology Process of (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

There total 10 articles about (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl (tert-butoxycarbonyl(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl)amino)acetate (1187450-65-2) → (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid (1187451-41-7)

Guidance literature:

tert-butyl (tert-butoxycarbonyl(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl)amino)acetate; With hydrogenchloride; water; at 65 ℃; for 2.5h;

With sodium hydroxide; pH=4 - 5;

Reference yield:

tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate (1187450-49-2) → (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid (1187451-41-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydroxylamine hydrochloride; pyridine / 1 h / 20 °C

3.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

6.1: hydrogenchloride; water / 2.5 h / 65 °C

6.2: pH 4 - 5

With pyridine; hydrogenchloride; tributylphosphine; diamide; hydroxylamine hydrochloride; water; hydrogen; Dess-Martin periodane; triethylamine; palladium; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

tert-butyl [tert-butoxycarbonyl(6-hydroxyiminomethylpyridin-2-yl)amino]acetate (1187451-30-4) → (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid (1187451-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

4.1: hydrogenchloride; water / 2.5 h / 65 °C

4.2: pH 4 - 5

With hydrogenchloride; tributylphosphine; diamide; water; hydrogen; triethylamine; palladium; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

tert-butyl (tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

tert-butyl [tert-butoxycarbonyl(6-formylpyridin-2-yl)amino]acetate

Downstream raw materials:

(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

isopropyl 2-{[6-({N-[4-(1H-pyrazol-1-yl)benzyl]pyridine-3-sulfonamido}methyl)pyridin-2-yl]amino}acetate