(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Base Information

Chemical Name:(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid
CAS No.:1187451-41-7
Molecular Formula:C₂₃H₂₂N₆O₄S
Molecular Weight:478.531
Hs Code.:

Synonyms:(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Suppliers and Price of (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Omidenepag
1mg
$ 195.00

DC Chemicals
Omidenepag >98%
250 mg
$ 1800.00

DC Chemicals
Omidenepag >98%
100 mg
$ 990.00

ChemScene
Omidenepag 99.78%
100mg
$ 4600.00

ChemScene
Omidenepag 99.78%
50mg
$ 3000.00

ChemScene
Omidenepag 99.78%
5mg
$ 500.00

ChemScene
Omidenepag 99.78%
10mg
$ 850.00

ChemScene
Omidenepag 99.78%
25mg
$ 1800.00

Biosynth Carbosynth
Omidenepag
25 mg
$ 1600.00

Biorbyt Ltd
Omidenepag >98%
25 mg
$ 1283.50

Total 7 raw suppliers

Chemical Property of (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Chemical Property:

Boiling Point:769.4±70.0 °C(Predicted)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Omidenepag ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Omidenepag, is a novel selective, non-prostanoid EP2 receptor agonist for the treatment of Glaucoma:

Technology Process of (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

There total 10 articles about (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1187450-65-2
tert-butyl (tert-butoxycarbonyl(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl)amino)acetate

: 1187451-41-7
(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Guidance literature:: tert-butyl (tert-butoxycarbonyl(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl)amino)acetate; With hydrogenchloride; water; at 65 ℃; for 2.5h;

With sodium hydroxide; pH=4 - 5;

Reference yield:

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1187451-41-7
(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydroxylamine hydrochloride; pyridine / 1 h / 20 °C

3.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

6.1: hydrogenchloride; water / 2.5 h / 65 °C

6.2: pH 4 - 5

With pyridine; hydrogenchloride; tributylphosphine; diamide; hydroxylamine hydrochloride; water; hydrogen; Dess-Martin periodane; triethylamine; palladium; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 1187451-30-4
tert-butyl [tert-butoxycarbonyl(6-hydroxyiminomethylpyridin-2-yl)amino]acetate

: 1187451-41-7
(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

4.1: hydrogenchloride; water / 2.5 h / 65 °C

4.2: pH 4 - 5

With hydrogenchloride; tributylphosphine; diamide; water; hydrogen; triethylamine; palladium; In tetrahydrofuran; ethanol; dichloromethane; water;