(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

Base Information

Chemical Name:(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate
CAS No.:1273387-12-4
Molecular Formula:C₂₅H₂₃F₃N₆O₄S
Molecular Weight:560.557
Hs Code.:

Synonyms:(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

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Chemical Property of (2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

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Technology Process of (2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

There total 8 articles about (2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 75-89-8
2,2,2-trifluoroethanol

: 1187451-41-7
(6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

: 1273387-12-4
(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: 2,2,2-trifluoroethanol; (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid; With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 24h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1187451-25-7
tert-butyl [tert-butoxycarbonyl(6-ethoxycarbonylpyridine-2-yl)amino]acetate

: 1273387-12-4
(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 35 °C / Cooling with ice

1.2: 1.17 h / 29 °C / Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: hydroxylamine hydrochloride; pyridine / 1 h / 20 °C

4.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

5.1: triethylamine / dichloromethane / 1 h / 20 °C

6.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

7.1: hydrogenchloride; water / 2.5 h / 65 °C

7.2: pH 4 - 5

8.1: hydrogenchloride / 1,4-dioxane / 24 h / 60 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; hydroxylamine hydrochloride; water; hydrogen; Dess-Martin periodane; triethylamine; calcium chloride; palladium; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; Tetraethylene glycol dimethyl ether; water;

Reference yield:

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1273387-12-4
(2,2,2-trifluoroethyl) (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydroxylamine hydrochloride; pyridine / 1 h / 20 °C

3.1: hydrogen / palladium / ethanol; water / 1 h / 20 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

6.1: hydrogenchloride; water / 2.5 h / 65 °C

6.2: pH 4 - 5

7.1: hydrogenchloride / 1,4-dioxane / 24 h / 60 °C

With pyridine; hydrogenchloride; tributylphosphine; diamide; hydroxylamine hydrochloride; water; hydrogen; Dess-Martin periodane; triethylamine; palladium; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;