(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

Base Information

Chemical Name:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester
CAS No.:1394048-69-1
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

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Chemical Property of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

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Technology Process of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

There total 8 articles about (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16681-70-2
1H-1,2,3-triazole-4-carboxylic acid

: C₂HF₃O₂*C₂₀H₂₅NO₃

: 1394048-69-1
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

Guidance literature:: 1H-1,2,3-triazole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

C₂HF₃O₂*C₂₀H₂₅NO₃; In dichloromethane; for 2h;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1394048-69-1
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 9 h / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: 3 h / 80 °C / Inert atmosphere

5.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.2: pH 7

6.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

6.2: 2 h / -5 °C

6.3: pH 7

7.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

8.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

9.2: 2 h

With dmap; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1174130-65-4
(R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1394048-69-1
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: pH 7

2.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C

2.3: pH 7

3.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

5.2: 2 h

With potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; water;