2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI&

Base Information

• Chemical Name: 2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI&
• CAS No.: 942-70-1
• Molecular Formula: C8H6FN3S
• Molecular Weight: 195.22
• Hs Code.: 2934999090
• Mol file: 942-70-1.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-(p-fluorophenyl)- (7CI,8CI);2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole;5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-amine;5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-ylamine;

Chemical Property of 2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI&

Chemical Property:

• Vapor Pressure: 3.98E-05mmHg at 25°C
• Melting Point: 238-243 °C
• Refractive Index: 1.643
• Boiling Point: 351.9 °C at 760 mmHg
• Flash Point: 166.6 °C
• PSA: 80.04000
• Density: 1.423 g/cm³
• LogP: 2.50760

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole can be used as a substrate in the preparation of:Bithiophene based azo dyes with possible nonlinear optical (NLO) properties.4-Thiazolidinone derivatives as potent HCV NS5B polymerase inhibitors.1,3,4-Thiadiazole and phenothiazine hybrids as possible antitubercular agents.

Technology Process of 2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI&

There total 13 articles about 2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-fluorobenzylidenehydrazinyl)thiocarboxamide (459-38-1) → 5-(4-fluorophenyl)-1,3,4-thiadiazol-2-amine (942-70-1)

Guidance literature:

With iron(III) chloride; In water; for 0.05h; Microwave irradiation; Sonication; Green chemistry;

DOI:10.1007/s00706-012-0846-x

Reference yield: 86.0%

potassium thioacyanate (333-20-0) + 4-fluorobenzaldehyde (459-57-4) → 5-(4-fluorophenyl)-1,3,4-thiadiazol-2-amine (942-70-1)

Guidance literature:

With iodine; toluene-4-sulfonic acid hydrazide; In dimethyl sulfoxide; at 100 ℃; for 12h; Sealed tube;

DOI:10.1002/ejoc.201901250

Reference yield: 84.0%

4-Fluorobenzoic acid (456-22-4) + thiosemicarbazide (79-19-6) → 5-(4-fluorophenyl)-1,3,4-thiadiazol-2-amine (942-70-1)

Guidance literature:

4-Fluorobenzoic acid; thiosemicarbazide; With trichlorophosphate; at 75 ℃; for 0.5h;

With water; for 4h; Reflux;

DOI:10.1016/j.bmc.2014.09.039

upstream raw materials:

2-(4-fluorobenzoyl)hydrazinecarbothioamide

(4-fluorobenzylidenehydrazinyl)thiocarboxamide

4-Fluorobenzoic acid

thiosemicarbazide

Downstream raw materials:

N-[5-(4-fluoro-phenyl)-[1,3,4]thiadiazol-2-yl]-benzamidine

4-[[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-ylimino]-methyl]phenol

KUC₀₆₀₁₁₄