(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

Base Information

Chemical Name:(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one
CAS No.:1149764-69-1
Molecular Formula:C₂₃H₃₆O₃Si
Molecular Weight:388.623
Hs Code.:

Synonyms:(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

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Chemical Property of (6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

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Technology Process of (6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

There total 12 articles about (6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1149764-68-0
(4S,6R)-6-(tert-butyldimethyl silanyloxy)-10-phenyldec-1-en-4-yl acrylate

: 1149764-69-1
(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 55 ℃; for 12h;
DOI:10.1016/j.tet.2009.01.101

Reference yield:

: 1149764-67-9
(4S,6R)-6-(tert-butyldimethylsilanyloxy)-10-phenyldec-1-en-4-ol

: 1149764-69-1
(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

2: Grubbs catalyst first generation / dichloromethane / 24 h / Reflux; Inert atmosphere

With Grubbs catalyst first generation; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.tetasy.2011.09.017

Reference yield:

: 1160697-63-1
tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

: 1149764-69-1
(6S)-5,6-dihydro-6-[(2R)-2-(tert-butyldimethyl silanyloxy)-6-phenylhexyl]-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere

1.2: Saturated solution; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

3.1: Grubbs catalyst first generation / dichloromethane / 24 h / Reflux; Inert atmosphere

With Grubbs catalyst first generation; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.09.017