1160697-63-1Relevant academic research and scientific papers
An organocatalytic route to the synthesis of (6S)-5,6-dihydro-6-[(2R)-2- hydroxy-6-phenylhexyl]-2H-pyran-2-one and ravensara lactones
Dwivedi, Namrata,Tripathi, Divya,Kumar, Pradeep
, p. 1749 - 1756 (2012/02/03)
An organocatalytic enantioselective synthesis of the title compounds has been achieved. The stereogenic centers were generated by the iterative use of proline catalyzed α-aminoxylations and HWE olefination of aldehydes while the lactone ring was construct
Stereoselective total synthesis of a potent natural antifungal compound (6S)-5,6,dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one
Das, Biswanath,Laxminarayana, Keetha,Krishnaiah, Martha,Kumar, Duddukuri Nandan
scheme or table, p. 6396 - 6398 (2010/05/02)
A practical stereoselective synthesis of (6S)-5,6,dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one (1), a potent natural antifungal compound, is described. The sequence involves diastereoselective iodine-induced electrophilic cyclization, epoxide
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity
Nakagawa, Yu,Yanagita, Ryo C.,Hamada, Naoko,Murakami, Akira,Takahashi, Hideyuki,et al.
supporting information; experimental part, p. 7573 - 7579 (2009/10/17)
Protein kinase C (PKC) is widely recognized as a therapeutic target in intractable diseases such as cancer, Alzheimer's disease (AD), and acquired immune deficiency syndrome (AIDS). While inhibition of PKC is a general therapeutic strategy for the treatme
