tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

Base Information

Chemical Name:tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane
CAS No.:1160697-63-1
Molecular Formula:C₂₀H₃₄O₂Si
Molecular Weight:334.574
Hs Code.:

Synonyms:tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

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Chemical Property of tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

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Technology Process of tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

There total 10 articles about tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1201121-35-8
C₁₄H₂₀O₂

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1160697-63-1
tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2009.09.063

Reference yield: 82.0%

: 934473-34-4
(2R,4R)-4-(tert-butyldimethylsilyloxy)-8-phenyloctane-1,2-diol

: 1160697-63-1
tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

Guidance literature:: (2R,4R)-4-(tert-butyldimethylsilyloxy)-8-phenyloctane-1,2-diol; With di(n-butyl)tin oxide; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

With potassium carbonate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.09.017

Reference yield:

: C₂₁H₂₅NO₃

: 1160697-63-1
tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-6-phenylhexan-2-yloxy)silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 8 h

2.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 - 20 °C / Inert atmosphere

4.1: L-proline / dimethyl sulfoxide / 1 h / 25 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 760.05 Torr

7.1: di(n-butyl)tin oxide; triethylamine; p-toluenesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere

7.2: 1 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; di(n-butyl)tin oxide; triethylamine; p-toluenesulfonyl chloride; L-proline; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1016/j.tetasy.2011.09.017