3,6-Dichloropyridazine-4-carboxylic acid

Base Information

• Chemical Name: 3,6-Dichloropyridazine-4-carboxylic acid
• CAS No.: 51149-08-7
• Molecular Formula: C5H2Cl2N2O2
• Molecular Weight: 192.989
• Hs Code.: 29339900
• Mol file: 51149-08-7.mol

Synonyms:4-Pyridazinecarboxylicacid, 3,6-dichloro-;3,6-Dichloropyridazine-4-carboxylicacid;NSC 338209;

Chemical Property of 3,6-Dichloropyridazine-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 5.66E-08mmHg at 25°C
• Melting Point: 142 °C (dec.)(lit.)
• Refractive Index: 1.614
• Boiling Point: 424.8 °C at 760 mmHg
• PKA: 0.59±0.32(Predicted)
• Flash Point: 210.7 °C
• PSA: 63.08000
• Density: 1.718 g/cm³
• LogP: 1.48160
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dichloropyridazine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-Dichloropyridazine-4-carboxylic acid has been used in the synthesis of α-(halohetaroyl)-2-azahetarylacetonitriles.

Technology Process of 3,6-Dichloropyridazine-4-carboxylic acid

There total 1 articles about 3,6-Dichloropyridazine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichloro-4-methylpyridazine (19064-64-3) → 3,6-dichloropyridazin-4-carboxylic acid (51149-08-7) + 3-Hydroxy-6-chlor-4-pyridazin-carbonsaeure (50681-26-0)

Guidance literature:

With potassium dichromate; sulfuric acid; at 20 - 45 ℃; for 2.5h;

Reference yield: 100.0%

3,6-dichloropyridazin-4-carboxylic acid (51149-08-7) → 3,6-dichloropyridazine-5-carboxylic acid chloride (6531-08-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

Reference yield: 58.0%

2-(4-Chlorophenyl)ethanol (1875-88-3) + 3,6-dichloropyridazin-4-carboxylic acid (51149-08-7) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 6-chloro-3-(4-chlorophenethoxy)pyridazine-4-carboxylate

Guidance literature:

2-(4-Chlorophenyl)ethanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 2 ℃; for 0.5h; Inert atmosphere;

3,6-dichloropyridazin-4-carboxylic acid; In tetrahydrofuran; mineral oil; at 2 - 60 ℃;

diazomethyl-trimethyl-silane; In methanol; hexane; dichloromethane;

upstream raw materials:

3,6-dichloro-4-methylpyridazine

Downstream raw materials:

ethyl 3,6-dichloropyridazine-4-carboxylate

tert-butyl 3,6-dichloropyridazine-4-carboxylate

3,6-dichloropyridazine-5-carboxylic acid chloride

6-chloro-3-(2-fluoro-4-iodo-phenylamino)-pyridazine-4-carboxylic acid

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