tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

Base Information

Chemical Name:tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate
CAS No.:1398708-33-2
Molecular Formula:C₂₂H₂₃Cl₂NO₄
Molecular Weight:436.335
Hs Code.:

Synonyms:tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

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Chemical Property of tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

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Technology Process of tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

There total 4 articles about tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1398705-03-7
tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

: 98-88-4
benzoyl chloride

: 1398708-33-2
tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield:

: 177947-96-5
tert-butyl 3-formylazetidine-1-carboxylate

: 1398708-33-2
tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C

With dmap; triethylamine; In tetrahydrofuran; dichloromethane; 1: |Grignard Reaction;
DOI:10.1021/jm3008294

Reference yield:

: 142253-56-3
3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester

: 1398708-33-2
tertiary butyl 3-((benzoyloxy)(3,4-dichlorophenyl)methyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C

With dmap; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Grignard Reaction;
DOI:10.1021/jm3008294