(3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine

Base Information

• Chemical Name: (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine
• CAS No.: 165319-96-0
• Molecular Formula: C₂₉H₂₉N₃O₆S₂
• Molecular Weight: 579.698

Synonyms:(3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine

Chemical Property of (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine

There total 2 articles about (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(tert-butyl-3'-O-benzyl-3'-deoxy-β-D-ribo-furanuronate)-1-thymine (165319-94-8) → (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine (165319-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CF₃COOH / CH₂Cl₂ / 3 h / 0 °C

2: 1.) N-methylmorpholine, isobutyl chloroformate

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;

DOI:10.1016/S0957-4166(00)86288-6

Reference yield:

PVS (5535-48-8) + 2-mercaptopyridine-1-oxide sodium salt (3811-73-2) + (3'-O-benzyl-3'-deoxy-β-D-ribo-furanuronic acid)-1-thymine (165319-95-9) → (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-L-ribo-hexofuranosyl)-1-thymine + (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine (165319-96-0)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0957-4166(00)86288-6

Reference yield: 81.0%

(3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine (165319-96-0) → (3'-O-benzyloxy-6'-phenylsulphonyl-2',5',6'-trideoxy-β-D-ribo-5'-ene-hexofuranosyl)-1-thymine

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0957-4166(00)86288-6

upstream raw materials:

PVS

2-mercaptopyridine-1-oxide sodium salt

(3'-O-benzyl-3'-deoxy-β-D-ribo-furanuronic acid)-1-thymine

(tert-butyl-3'-O-benzyl-3'-deoxy-β-D-ribo-furanuronate)-1-thymine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 165319-96-0 (3'-O-benzyloxy-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine

Send

Send

Metric Ton KG G Pound L ML

Send

Send