METHYL 3-PYRROLIDINECARBOXYLATE HCL

Base Information

• Chemical Name: METHYL 3-PYRROLIDINECARBOXYLATE HCL
• CAS No.: 198959-37-4
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Hs Code.: 2933990090
• Mol file: 198959-37-4.mol

Synonyms:Methyl pyrrolidine-3-carboxylatehydrochloride;3-Pyrrolidinecarboxylicacid, methyl ester, hydrochloride (9CI);

Chemical Property of METHYL 3-PYRROLIDINECARBOXYLATE HCL

Chemical Property:

• Vapor Pressure: 0.135mmHg at 25°C
• Boiling Point: 213.6 °C at 760 mmHg
• Flash Point: 83 °C
• PSA: 38.33000
• LogP: 0.89970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methylpyrrolidine-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-PYRROLIDINECARBOXYLATE HCL

There total 1 articles about METHYL 3-PYRROLIDINECARBOXYLATE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (S)-(+)-3-pyrrolidinecarboxylic acid (72580-53-1) → methyl (S)-pyrrolidine-3-carboxylate hydrochloride (1099646-61-3,198959-37-4)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3h;

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-methyl pyrrolidine-3-carboxylate hydrochloric acid (198959-37-4) → (R)-methyl-1-tert-butoxycarbonyl-pyrrolidine-3-carboxylate (441717-40-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

pyrrolidine-3-carboxylic acid methyl ester hydrochloride (198959-37-4) → 1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate (912444-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran; water / 2 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: -78 - 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water;

upstream raw materials:

methanol

(S)-(+)-3-pyrrolidinecarboxylic acid

Downstream raw materials:

(R)-methyl-1-tert-butoxycarbonyl-pyrrolidine-3-carboxylate

1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate

Refernces

• 1、 -. "PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE". Page/Page column 50; 89. . Retrieved 2019/11/04.