methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

Base Information

Chemical Name:methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate
CAS No.:1394136-35-6
Molecular Formula:C₁₅H₁₂F₄N₂O₄
Molecular Weight:360.265
Hs Code.:

Synonyms:methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

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Chemical Property of methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

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Technology Process of methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

There total 4 articles about methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₀F₄N₂O₄

: 74-88-4
methyl iodide

: 1394136-35-6
methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

Guidance literature:: C₁₄H₁₀F₄N₂O₄; With potassium carbonate; In acetone; for 0.5h;

methyl iodide; In acetone; for 24h; Reflux;
DOI:10.1016/j.ejmech.2012.04.020

Reference yield:

: 1059626-05-9,1000805-93-5
(4-fluorobenzyl)-hydrazine hydrochloride

: 1394136-35-6
methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / diethyl ether / 10 h

2.1: hydrogenchloride / water / 0 °C / pH 2 - 3

3.1: potassium carbonate / acetone / 0.5 h

3.2: 24 h / Reflux

With hydrogenchloride; potassium carbonate; In diethyl ether; water; acetone;
DOI:10.1016/j.ejmech.2012.04.020

Reference yield:

: dimethyl 2-<(1-methylethyl)amino>-3-(trifluoroacetyl)-2-butenedioate

: 1394136-35-6
methyl 1-(4-fluorobenzyl)-5-methoxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / diethyl ether / 10 h

2.1: hydrogenchloride / water / 0 °C / pH 2 - 3

3.1: potassium carbonate / acetone / 0.5 h

3.2: 24 h / Reflux

With hydrogenchloride; potassium carbonate; In diethyl ether; water; acetone;
DOI:10.1016/j.ejmech.2012.04.020