5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

Base Information

Chemical Name:5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole
CAS No.:1366767-39-6
Molecular Formula:C₂₃H₂₂N₆O
Molecular Weight:398.467
Hs Code.:

Synonyms:5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

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Chemical Property of 5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

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Technology Process of 5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

There total 4 articles about 5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 862723-42-0
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole

: 1366767-93-2
C₁₆H₁₇BrN₄O

: 1366767-39-6
5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 5933-32-4
4-bromobenzoic acid hydrazide

: 1366767-39-6
5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 2 h / 110 °C

2.1: tetrahydrofuran / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 2 h / 0 - 20 °C / Cooling with ice

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1366767-92-1
1,1-dimethylethyl 3-{[3-(4-bromophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

: 1366767-39-6
5-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)phenyl]-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 2 h / 0 - 20 °C / Cooling with ice

2.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water;