3-Methoxy-4-pyridinecarboxylic acid

Base Information

• Chemical Name: 3-Methoxy-4-pyridinecarboxylic acid
• CAS No.: 654663-32-8
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• Mol file: 654663-32-8.mol

Synonyms:3-Methoxyisonicotinic acid;4-Pyridinecarboxylicacid, 3-methoxy-;3-Methoxypyridine-4-carboxylic acid;

Chemical Property of 3-Methoxy-4-pyridinecarboxylic acid

Chemical Property:

• Refractive Index: 1.549
• Boiling Point: 399.5 °C at 760 mmHg
• PKA: 1.84±0.10(Predicted)
• Flash Point: 195.4 °C
• PSA: 59.42000
• Density: 1.284 g/cm³
• LogP: 0.78840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-4-pyridinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-4-pyridinecarboxylic acid

There total 4 articles about 3-Methoxy-4-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxypyridine-4-carbonitrile (26414-90-4) → 3-methoxypyridine-4-carboxylic acid (654663-32-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; at 20 ℃; for 20h; pH=3; Reflux;

DOI:10.1021/jm301247n

Reference yield:

3-methoxyisonicotinonitrile (1256817-05-6) → 3-methoxypyridine-4-carboxylic acid (654663-32-8)

Guidance literature:

3-methoxyisonicotinonitrile; With sodium hydroxide; In ethanol; for 20h; Reflux;

With hydrogenchloride; In ethanol; pH=3;

Reference yield:

pyridine-4-carbonitrile (100-48-1) → 3-methoxypyridine-4-carboxylic acid (654663-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 0.5 h / -80 °C / Inert atmosphere

1.2: 0.5 h / -80 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 2.5 h / Cooling with ice

3.1: sodium hydroxide; hydrogenchloride / ethanol / 20 h / 20 °C / pH 3 / Reflux

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm301247n

upstream raw materials:

3-methoxypyridine-4-carbonitrile

3-methoxyisonicotinonitrile

pyridine-4-carbonitrile

3-chloro-isonicotinonitrile

Downstream raw materials:

methyl 3-methoxy-4-pyridinecarboxylate

3-methoxy-4-pyridinecarboxaldehyde

4-(hydroxymethyl)-3-methoxypyridine