(3-Methoxypyridin-4-yl)methanol

Base Information

• Chemical Name: (3-Methoxypyridin-4-yl)methanol
• CAS No.: 102074-60-2
• Molecular Formula: C7H9 N O2
• Molecular Weight: 139.15
• DSSTox Substance ID: DTXSID80600123
• Wikidata: Q82496086
• Mol file: 102074-60-2.mol

Synonyms:(3-Methoxypyridin-4-yl)methanol;102074-60-2;4-Pyridinemethanol,3-methoxy-(6CI,9CI);4-pyridinemethanol,3-methoxy-;SCHEMBL5114144;4-Pyridinemethanol, 3-methoxy-;DTXSID80600123;BAHUOCIALOMKRJ-UHFFFAOYSA-N;AMY17661;CEA07460;MFCD16606979;SB15806;DA-48332;SY322145;CS-0054446;P11879

Chemical Property of (3-Methoxypyridin-4-yl)methanol

Chemical Property:

• PSA: 42.35000
• LogP: 0.58250
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

NLT 98% ^*data from raw suppliers

(3-Methoxypyridin-4-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CN=C1)CO

Technology Process of (3-Methoxypyridin-4-yl)methanol

There total 4 articles about (3-Methoxypyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

3-methoxypyridine-4-carboxylic acid (654663-32-8) → 4-(hydroxymethyl)-3-methoxypyridine (102074-60-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 85 ℃; for 32h; Inert atmosphere;

Reference yield: 22.0%

methyl 3-methoxy-4-pyridinecarboxylate (59786-32-2) → 4-(hydroxymethyl)-3-methoxypyridine (102074-60-2)

Guidance literature:

methyl 3-methoxy-4-pyridinecarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

With Rochelle's salt; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jacs.7b12768

Reference yield:

3-hydroxyisonicotinic acid (10128-71-9) → 4-(hydroxymethyl)-3-methoxypyridine (102074-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated H₂SO₄; 1,2-dichloro-ethane

2: diethyl ether; ethanol

3: lithium alanate; diethyl ether

With lithium aluminium tetrahydride; diethyl ether; ethanol; sulfuric acid; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4020(01)82610-7

upstream raw materials:

methyl 3-methoxy-4-pyridinecarboxylate

3-hydroxyisonicotinic acid

methyl 3-hydroxypyridine-4-carboxylate

3-methoxypyridine-4-carboxylic acid

Downstream raw materials:

3-methoxy-4-pyridinecarboxaldehyde