5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Base Information

Chemical Name:5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile
CAS No.:1448428-01-0
Molecular Formula:C₁₄H₁₂FN₃S
Molecular Weight:273.334
Hs Code.:

Synonyms:5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Suppliers and Price of 5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

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Chemical Property of 5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

There total 4 articles about 5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 627871-16-3
5-bromo-4-fluoro-2-methylaniline

: 1448428-01-0
5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 3 h / 180 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C / Inert atmosphere

3.1: acetic acid / 4 h / 110 °C

With potassium carbonate; acetic acid; potassium iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 1426136-04-0
5-amino-2-fluoro-4-methylbenzonitrile

: 1448428-01-0
5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

1.2: 3 h / 60 °C / Inert atmosphere

2.1: acetic acid / 4 h / 110 °C

With potassium carbonate; acetic acid; potassium iodide; In N,N-dimethyl-formamide;

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 1448428-01-0
5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 2 h / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 18 h / 100 °C / Inert atmosphere

3: acetic acid / 5 h / 110 °C / Inert atmosphere

With acetic acid; N-ethyl-N,N-diisopropylamine; In acetonitrile;