Selonsertib HCl salt, GS-4997 HCl salt

Base Information

Chemical Name:Selonsertib HCl salt, GS-4997 HCl salt
CAS No.:1448428-05-4
Molecular Formula:C₂₄H₂₄FN₇O*ClH
Molecular Weight:481.96
Hs Code.:

Synonyms:5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

Suppliers and Price of Selonsertib HCl salt, GS-4997 HCl salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
SelonsertibHydrochloride
100mg
$ 1510.00

Adipogen Life Sciences
Selonsertib.hydrochloride ≥95%
5 mg
$ 205.00

Total 3 raw suppliers

Chemical Property of Selonsertib HCl salt, GS-4997 HCl salt

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

SelonsertibHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Selonsertib HCl salt, GS-4997 HCl salt

There total 9 articles about Selonsertib HCl salt, GS-4997 HCl salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448427-99-3
6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine

: C₁₄H₁₂ClFN₂O*ClH

: 1448428-05-4
5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 627871-16-3
5-bromo-4-fluoro-2-methylaniline

: 1448428-05-4
5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-methyl-pyrrolidin-2-one / 3 h / 180 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C / Inert atmosphere

3.1: acetic acid / 4 h / 110 °C

4.1: dihydrogen peroxide; water / acetic acid / 1 h / 45 - 55 °C / Inert atmosphere

5.1: hydrogenchloride; water / 4.5 h / 100 °C / Reflux

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Inert atmosphere

7.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; oxalyl dichloride; water; dihydrogen peroxide; potassium carbonate; acetic acid; N,N-dimethyl-formamide; potassium iodide; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1448428-00-9
5-((2-cyclopropyl-2-oxoethyl)amino)-2-fluoro-4-methylbenzonitrile

: 1448428-05-4
5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 4 h / 110 °C

2: dihydrogen peroxide; water / acetic acid / 1 h / 45 - 55 °C / Inert atmosphere

3: hydrogenchloride; water / 4.5 h / 100 °C / Reflux

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; oxalyl dichloride; water; dihydrogen peroxide; acetic acid; N,N-dimethyl-formamide; In dichloromethane; acetic acid;