3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]-

Base Information

Chemical Name:3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]-
CAS No.:179234-02-7
Molecular Formula:C19H18 O6
Molecular Weight:342.348
Hs Code.:

Synonyms:3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxy-1-propenyl)-, (E)-;3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propenyl]- (9CI);Vibsanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]-

There total 18 articles about 3-Benzofuranmethanol,7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 238098-84-5
{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

: 179234-02-7
vibsanol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 32h;
DOI:10.3987/com-99-s63

Reference yield: 99.0%

: {7-(2-Ethoxy-ethoxy)-2-[4-(2-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(2-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

: 179234-02-7
vibsanol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol;
DOI:10.1016/S0040-4039(99)00714-5

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 179234-02-7
vibsanol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / PPTS / tetrahydrofuran / 30 h / 20 °C

2: 76 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

3: 60 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

4: 67 percent / molecular sieves 4 Angstroem; TBAF / tetrahydrofuran / 3 h / 50 °C

5: 99 percent / PPTS / methanol / 32 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; methanol; hexane; toluene; 1: Etherification / 2: homologation / 3: Sonogashira cross coupling / 4: Cyclization / 5: Substitution;
DOI:10.3987/com-99-s63