{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

Base Information

Chemical Name:{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol
CAS No.:238098-84-5
Molecular Formula:C₃₁H₄₂O₉
Molecular Weight:558.669
Hs Code.:

Synonyms:{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

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Chemical Property of {7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

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Technology Process of {7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

There total 10 articles about {7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 238098-83-4
2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

: 7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran

: 238098-84-5
{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

Guidance literature:: With 4 A molecular sieve; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.3987/com-99-s63

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 238098-84-5
{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / PPTS / tetrahydrofuran / 30 h / 20 °C

2: 76 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

3: 60 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

4: 67 percent / molecular sieves 4 Angstroem; TBAF / tetrahydrofuran / 3 h / 50 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; hexane; toluene; 1: Etherification / 2: homologation / 3: Sonogashira cross coupling / 4: Cyclization;
DOI:10.3987/com-99-s63

Reference yield:

: 35615-21-5
3-methoxy-4-(ethoxyethylidene-oxy)-benzaldehyde

: 238098-84-5
{7-(1-Ethoxy-ethoxy)-2-[4-(1-ethoxy-ethoxy)-3-methoxy-phenyl]-5-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-benzofuran-3-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

2: 60 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

3: 67 percent / molecular sieves 4 Angstroem; TBAF / tetrahydrofuran / 3 h / 50 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; hexane; toluene; 1: homologation / 2: Sonogashira cross coupling / 3: Cyclization;
DOI:10.3987/com-99-s63