ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

Base Information

Chemical Name:ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate
CAS No.:138366-04-8
Molecular Formula:C₂₀H₁₇ClN₄O₂
Molecular Weight:380.834
Hs Code.:

Synonyms:ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

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Chemical Property of ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

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Technology Process of ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

There total 9 articles about ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 138366-03-7
ethyl 8-nitro-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

: 138366-04-8
ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

Guidance literature:: With ammonium hydroxide; hydrogen; nickel; In tetrahydrofuran; ethanol; under 2068.6 Torr;
DOI:10.1002/jhet.5570280704

Reference yield:

: 106-39-8
bromochlorobenzene

: 138366-04-8
ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 1) Mg 2) 2N HCl / 1) Et₂O, reflux, 30 min 2) Et₂O, reflux, 1 h

2: 98 percent / aq. 20percent Na₂CO₃ / diethyl ether; H₂O / 1 h / Ambient temperature

3: NH₃ / CH₂Cl₂ / 3 h / Heating

4: ethanol / 3 h / Heating

5: 63 percent / KNO₃, conc. H₂SO₄ / 1) 0 deg C, 30 min 2) r.t., 4 h

6: t-BuOK / tetrahydrofuran / 0.5 h

7: t-BuOK / tetrahydrofuran / 1) 0 deg C, 1 h 2) r.t., overnight

8: 64 percent / H₂, 20percent ammonia / Raney-Ni / ethanol; tetrahydrofuran / 2068.6 Torr

With hydrogenchloride; ammonium hydroxide; sulfuric acid; potassium tert-butylate; ammonia; hydrogen; sodium carbonate; magnesium; potassium nitrate; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/jhet.5570280704

Reference yield:

: 2894-51-1
2-amino-4'-chlorobenzophenone

: 138366-04-8
ethyl 8-amino-6-(4-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / aq. 20percent Na₂CO₃ / diethyl ether; H₂O / 1 h / Ambient temperature

2: NH₃ / CH₂Cl₂ / 3 h / Heating

3: ethanol / 3 h / Heating

4: 63 percent / KNO₃, conc. H₂SO₄ / 1) 0 deg C, 30 min 2) r.t., 4 h

5: t-BuOK / tetrahydrofuran / 0.5 h

6: t-BuOK / tetrahydrofuran / 1) 0 deg C, 1 h 2) r.t., overnight

7: 64 percent / H₂, 20percent ammonia / Raney-Ni / ethanol; tetrahydrofuran / 2068.6 Torr

With ammonium hydroxide; sulfuric acid; potassium tert-butylate; ammonia; hydrogen; sodium carbonate; potassium nitrate; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/jhet.5570280704