2,3-Difluoro-4-methoxyphenylboronic acid

Base Information

• Chemical Name: 2,3-Difluoro-4-methoxyphenylboronic acid
• CAS No.: 170981-41-6
• Molecular Formula: C₇H₇BF₂O₃
• Molecular Weight: 187.939
• Hs Code.: 2931900090
• Mol file: 170981-41-6.mol

Synonyms:Boronicacid, (2,3-difluoro-4-methoxyphenyl)- (9CI);

Chemical Property of 2,3-Difluoro-4-methoxyphenylboronic acid

Chemical Property:

• Vapor Pressure: 0.000386mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 304.335 °C at 760 mmHg
• PKA: 7.67±0.58(Predicted)
• Flash Point: 137.857 °C
• PSA: 49.69000
• Density: 1.351 g/cm³
• LogP: -0.34680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3-Difluoro-4-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 2,3-Difluoro-4-methoxyphenylboronic acid

There total 4 articles about 2,3-Difluoro-4-methoxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Trimethyl borate (121-43-7,63156-11-6) + 2.3-difluoroanisole (134364-69-5) → (2,3-difluoro-4-methoxyphenyl)boronic acid (170981-41-6)

Guidance literature:

2.3-difluoroanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at -30 ℃; for 2h; Inert atmosphere;

Reference yield: 90.0%

hydrogenchloride (7647-01-0,15364-23-5) + Trimethyl borate (121-43-7,63156-11-6) + 1-ethoxy-2,3-difluorobenzene → (2,3-difluoro-4-methoxyphenyl)boronic acid (170981-41-6)

Guidance literature:

1-ethoxy-2,3-difluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - -60 ℃; for 1h; Inert atmosphere;

hydrogenchloride; Trimethyl borate; In tetrahydrofuran; cyclohexane; water; at -30 ℃;

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 1-bromo-2,3-difluoro-4-methoxybenzene (406482-22-2) → (2,3-difluoro-4-methoxyphenyl)boronic acid (170981-41-6)

Guidance literature:

1-bromo-2,3-difluoro-4-methoxybenzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.75h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; pentane; for 16h;

With hydrogenchloride; water; In tetrahydrofuran; pentane; for 2h;

upstream raw materials:

Trimethyl borate

1-bromo-2,3-difluoro-4-methoxybenzene

2,3-difluoro-4-bromophenol

2.3-difluoroanisole

Downstream raw materials:

4-(azetidin-1-yl)-5-[5-(2,3-difluoro-4-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazine

C₁₇H₁₄F₂N₆O₂

C₁₇H₁₅F₂NO₄

C₂₄H₂₃F₂N₃O₅S