134364-69-5

Basic information

• Product Name: 2,3-Difluoroanisole
• Synonyms: 2,3-DIFLUOROANISOLE;1,2-DIFLUORO-3-METHOXYBENZENE;BENZENE, 1,2-DIFLUORO-3-METHOXY-;Difluoroanisole1;2,3-Difluoroanisole, 97+%;3-Difluoroanisole;1,2-Difluoro-3-methoxybenzene, 2,3-Difluorophenyl methyl ether;2,3-two fluorineether
• CAS NO: 134364-69-5
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.12
• Product Categories: blocks;FluoroCompounds;Aromatic Halides (substituted);Phenyls & Phenyl-Het;Fluorobenzene;Phenyls & Phenyl-Het;Fluorine series
• Mol File: 134364-69-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 144.5 °C at 760 mmHg
• Flash Point: 62°(144°F)
• Appearance: Colorless liquid
• Density: 1.24
• Vapor Pressure: 6.4mmHg at 25°C
• Refractive Index: 1.4710-1.4750
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,3-Difluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoroanisole(134364-69-5)
• EPA Substance Registry System: 2,3-Difluoroanisole(134364-69-5)

Safety Data

• Hazard Codes: F,Xi,Xn
• Statements: 10-36/37/38-22
• Safety Statements: 16-26-36-37
• RIDADR: 1993
• HazardClass: IRRITANT, FLAMMABLE
• PackingGroup: III
• Hazardous Substances Data: 134364-69-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C7H6F2O/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 1489-53-8 1,2,3-trifluorobenzene 
• 100-66-3 methoxybenzene 
• 6418-38-8 2,3-difluorophenol 
• 74-88-4 methyl iodide 
• 3862-73-5 2,3,4-trifluoroaniline 

Downstream Products

• 256417-11-5 2,3-difluoro-4-methoxy-benzaldehyde 
• 1023023-24-6 2-methoxy-3,4-difluorobenzaldehyde 
• 406482-22-2 1-bromo-2,3-difluoro-4-methoxybenzene 
• 1178859-06-7 2,5-Difluoro-4-methoxybenzophenone 
• 1178859-01-2 2'-Chloro-2,5-difluoro-4-methoxybenzophenone 
• 1093857-88-5 2,3-Difluoro-4-methoxy-1-propionylbenzene 
• 1358579-75-5 (5-bromo-2-chloro-phenyl)-(2,3-difluoro-4-methoxyphenyl)methanone 
• 1358579-77-7 (5-bromo-2-chloro-phenyl)-(2,3-difluoro-4-methoxy-phenyl)methanol 
• 1358579-80-2 1-[(5-bromo-2-chloro-phenyl)methyl]-2,3-difluoro-4-methoxy-benzene 
• 1358579-82-4 (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-6-(hydroxymethyl)-2-methoxy-tetrahydropyran-3,4,5-triol 
• 1358579-90-4 [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol 
• 1358579-94-8 (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde 
• 1358579-96-0 (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-carbaldehyde 
• 1358579-99-3 [(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol 

Relevant articles and documents

Microwave fluorination: A novel, rapid approach to fluorination with Selectfluor

Fluorination of electron rich aromatic systems with electrophilic fluorination reagents such as Selectfluor and Accufluor is a well-established process. Herein we report results from investigations into the use of such procedures to perform rapid, small-scale fluorinations under microwave irradiation. We have investigated the transformation with a range of different substrates and discuss the effects of two key factors, namely reaction time and choice of fluorination reagent. The use of Selectfluor in acetonitrile at 150°C with microwave heating for 10 min affords products in comparable yields to those obtained by prolonged heating in acetonitrile at its reflux temperature.

Synthesis technology of 2,3-difluorophenol

The invention relates to a synthesis technology of 2,3-difluorophenol. 1,2,3-trifluoro-benzene is used as a raw material, and 2,3-difluorophenol is prepared through oxyalkylation and dealkylation reactions. The synthesis route is short, the technology operation is simple, special equipment is not needed, the yield reaches 82% or above, and the synthesis technology has good industrial prospects.

GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE

Disclosed are glucopyranosyl derivatives used as sodium dependent glucose cotransporters (SGLTs) inhibitors, intermediates or preparation processes thereof, and pharmaceutical uses thereof, especially glucopyranosyl derivatives represented by Formula (I), or pharmaceutically acceptable salts or all stereoisomers thereof, pharmaceutical compositions containing these derivatives and their uses for treatment of diabetes and diabetes-related diseases.

Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.