4-(6-METHOXY-NAPHTHALEN-2-YL)-BENZONITRILE

Base Information

• Chemical Name: 4-(6-METHOXY-NAPHTHALEN-2-YL)-BENZONITRILE
• CAS No.: 80493-89-6
• Molecular Formula: C₁₈H₁₃NO
• Molecular Weight: 259.307
• Mol file: 80493-89-6.mol

Synonyms:2-(4'-cyanophenyl)-6-methoxynaphthalene

Chemical Property of 4-(6-METHOXY-NAPHTHALEN-2-YL)-BENZONITRILE

Chemical Property:

Purity/Quality:

4-(6-Methoxynaphthalen-2-yl)benzonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(6-METHOXY-NAPHTHALEN-2-YL)-BENZONITRILE

There total 5 articles about 4-(6-METHOXY-NAPHTHALEN-2-YL)-BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromobenzenecarbonitrile (623-00-7) + CH3OC10H6MnCl → 2-(4'-cyanophenyl)-6-methoxynaphthalene (80493-89-6)

Guidance literature:

1,2-dimethoxyethane; bis(diphenylphosphino)propanepalladium(II) dichloride; In tetrahydrofuran; at 20 ℃; for 0.3h;

DOI:10.1016/S0022-328X(00)00891-3

Reference yield: 68.0%

4-(phenylsulfinyl)benzonitrile (618909-31-2) + (6-methoxy-2-naphthalene)boronic acid (156641-98-4) → 2-(4'-cyanophenyl)-6-methoxynaphthalene (80493-89-6)

Guidance literature:

With SIPr-PdCl₂-Py; sodium t-butanolate; In tetrahydrofuran; at 70 ℃; for 12h; regioselective reaction;

DOI:10.1021/acscatal.0c01462

Reference yield: 63.0%

4-bromobenzenecarbonitrile (623-00-7) + 2-Bromo-6-methoxynaphthalene (5111-65-9) → 2-(4'-cyanophenyl)-6-methoxynaphthalene (80493-89-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; magnesium; zinc(II) chloride; In tetrahydrofuran;

DOI:10.1002/hlca.19810640617

upstream raw materials:

4-bromobenzenecarbonitrile

2-Bromo-6-methoxynaphthalene

6-bromo-naphthalen-2-ol

4-(phenylsulfinyl)benzonitrile