7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

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Chemical Name:7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide
CAS No.:1403491-34-8
Molecular Formula:C₂₄H₂₄N₄O₃
Molecular Weight:416.48
Hs Code.:

Synonyms:7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

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Chemical Property of 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

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Technology Process of 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

There total 9 articles about 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1300031-57-5
4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1403491-34-8
7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 18h;

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1403491-34-8
7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere

1.2: 4 h / 90 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h

3.1: 1 h / 130 °C

4.1: diphenylether / 0.33 h / Reflux

5.1: sodium hydroxide; water / ethanol; water / Reflux

5.2: 40 °C / pH 4

6.1: trichlorophosphate / 4 h / 20 °C / Heating

6.2: 0.5 h / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

With water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;

Reference yield:

: 5399-03-1
2-iodo-1-methoxy-4-nitrobenzene

: 1403491-34-8
7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere

1.2: 4 h / 90 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h

3.1: 1 h / 130 °C

4.1: diphenylether / 0.33 h / Reflux

5.1: sodium hydroxide; water / ethanol; water / Reflux

5.2: 40 °C / pH 4

6.1: trichlorophosphate / 4 h / 20 °C / Heating

6.2: 0.5 h / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

With water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;