Technology Process of 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
There total 11 articles about 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide;
With
potassium hydroxide;
In
methanol;
for 0.333333h;
Cooling with ice;
With
[bis(acetoxy)iodo]benzene;
In
methanol;
for 3h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere
1.2: 4 h / 90 °C / Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h
3.1: 1 h / 130 °C
4.1: diphenylether / 0.33 h / Reflux
5.1: sodium hydroxide; water / ethanol; water / Reflux
5.2: 40 °C / pH 4
6.1: trichlorophosphate / 4 h / 20 °C / Heating
6.2: 0.5 h / Cooling with ice
7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C
8.1: potassium hydroxide / methanol / 0.33 h / Cooling with ice
8.2: 3 h
With
water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate;
5%-palladium/activated carbon;
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere
1.2: 4 h / 90 °C / Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h
3.1: 1 h / 130 °C
4.1: diphenylether / 0.33 h / Reflux
5.1: sodium hydroxide; water / ethanol; water / Reflux
5.2: 40 °C / pH 4
6.1: trichlorophosphate / 4 h / 20 °C / Heating
6.2: 0.5 h / Cooling with ice
7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C
8.1: potassium hydroxide / methanol / 0.33 h / Cooling with ice
8.2: 3 h
With
water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate;
5%-palladium/activated carbon;
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;
![7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide](/Databaselist/images/loading.webp)
