(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

Base Information

Chemical Name:(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate
CAS No.:887275-17-4
Molecular Formula:C₁₈H₂₁F₂N₅O₃S
Molecular Weight:425.459
Hs Code.:

Synonyms:(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

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Technology Process of (S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

There total 7 articles about (S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {4-[2,6-Difluoro-4-((R)-5-isothiocyanatomethyl-2-oxo-oxazolidin-3-yl)-phenyl]-piperazin-1-yl}-acetonitrile

: 67-56-1
methanol

: 887275-17-4
(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

Guidance literature:: Heating;
DOI:10.1016/j.bmcl.2006.01.109

Reference yield:

: (R)-5-Azidomethyl-3-(3,5-difluoro-4-piperazin-1-yl-phenyl)-oxazolidin-2-one

: 887275-17-4
(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 20 °C

2: 78 percent / aq. PPh₃ / tetrahydrofuran / 45 °C

3: Et₃N; ClCOOEt

4: Heating

With chloroformic acid ethyl ester; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.01.109

Reference yield:

: 887274-96-6
{4-[4-((R)-5-Azidomethyl-2-oxo-oxazolidin-3-yl)-2,6-difluoro-phenyl]-piperazin-1-yl}-acetonitrile

: 887275-17-4
(S)-N-[[3-[3,5-difluoro-4-[4-(cyanomethyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]-methyl]-O-methylthiocarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / aq. PPh₃ / tetrahydrofuran / 45 °C

2: Et₃N; ClCOOEt

3: Heating

With chloroformic acid ethyl ester; triethylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.01.109