(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

Base Information

Chemical Name:(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate
CAS No.:1415037-53-4
Molecular Formula:C₅₃H₆₀N₄O₇SSi₂
Molecular Weight:953.319
Hs Code.:

Synonyms:(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

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Chemical Property of (R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

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Technology Process of (R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

There total 15 articles about (R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1415037-59-0
(R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate

: 1415037-53-4
(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1039/c2cc36604e DOI:10.1039/c2cc36604e

Reference yield: 72.0%

: 636559-66-5
4-((tert-butyldiphenylsilyl)oxy)benzoic acid

: (S)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)propan-2-ol

: 1415037-53-4
(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.joc.0c00446

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1415037-53-4
(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C

2: sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogenphosphate / water; tert-butyl alcohol / 36 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 0 - 20 °C / pH 7

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: |Mitsunobu Displacement / 5: |Mitsunobu Displacement;
DOI:10.1039/c2cc36604e DOI:10.1039/c2cc36604e