(R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate

Base Information

• Chemical Name: (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate
• CAS No.: 1415037-59-0
• Molecular Formula: C₅₃H₆₀N₄O₅SSi₂
• Molecular Weight: 921.32
• Mol file: 1415037-59-0.mol

Synonyms:(R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate

Chemical Property of (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate

There total 9 articles about (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-1-(tert-butyldiphenylsilyloxy)-3-(4-hydroxybutoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate (1415037-59-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1039/c2cc36604e DOI:10.1039/c2cc36604e

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate (1415037-59-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C

2: sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogenphosphate / water; tert-butyl alcohol / 36 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 0 - 20 °C / pH 7

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: |Mitsunobu Displacement / 5: |Mitsunobu Displacement;

DOI:10.1039/c2cc36604e DOI:10.1039/c2cc36604e

Reference yield:

(S)-3-(4-(4-methoxybenzyloxy)butoxy)propan-1,2-diol (1415037-55-6) → (R)-1-(tert-butyldiphenylsilyloxy)-3-(4-(1-phenyl-1H-tetrazole-5-ylthio)butoxy)propan-2-yl 4-(tert-butyldiphenylsilyloxy)benzoate (1415037-59-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 0 - 20 °C / pH 7

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Mitsunobu Displacement / 4: |Mitsunobu Displacement;

DOI:10.1039/c2cc36604e DOI:10.1039/c2cc36604e

upstream raw materials:

(S)-3-(4-(4-methoxybenzyloxy)butoxy)propan-1,2-diol

tert-butylchlorodiphenylsilane

(S)-1-(4-methoxyphenyl)-13,13-dimethyl-12,12-diphenyl-2,7,11-trioxa-12-silatetradecan-9-ol

4-hydroxy-benzaldehyde

Downstream raw materials:

(R)-1-((tert-butyldiphenylsilyl)oxy)-3-(4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butoxy)-propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)benzoate

(S)-1-hydroxy-3-(4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butoxy)propan-2-yl 4-hydroxybenzoate

(+)-bretonin B

(R)-2-(acetyloxy)-1-{[(4E,6Z,8E)-dodeca-4,6,8-trien-1-yloxy]methyl}ethyl 4-(acetyloxy)benzoate