(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Base Information

Chemical Name:(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole
CAS No.:1349172-67-3
Molecular Formula:C₃₂H₃₆N₂O₄
Molecular Weight:512.649
Hs Code.:

Synonyms:(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Suppliers and Price of (3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

There total 5 articles about (3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1349172-44-6
(3aS,4R,5R,6R,7aS)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-hexahydrobenzo[d]oxazol-2(3H)-one

: 78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0
azetidine hydrochloride

: 1349172-67-3
(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Guidance literature:: (3aS,4R,5R,6R,7aS)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-hexahydrobenzo[d]oxazol-2(3H)-one; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 24h; Molecular sieve; Inert atmosphere;

azetidine hydrochloride; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 48h;

Reference yield:

: rac-(3aS,4R,5R,6R,7aS)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-hexahydrobenzo[d]oxazol-2(3H)-one

: 1349172-67-3
(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: Chiralpak IA column / hexane; ethanol

2.1: trimethoxonium tetrafluoroborate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 48 h / 20 °C

With trimethoxonium tetrafluoroborate; In ethanol; hexane; dichloromethane;

Reference yield:

: 130970-85-3
rac-((((1R,2R,6R)-6-((benzyloxy)methyl)cyclohex-3-ene-1,2-diyl)bis-(oxy))bis(methylene))dibenzene

: 1349172-67-3
(3aS,4R,5R,6R,7aS)-2-(azetidin-1-yl)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; water / dimethyl sulfoxide / 2.5 h / 10 - 20 °C

2.1: dichloromethane / 1.5 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 21.5 h / 20 °C / Reflux

4.1: Chiralpak IA column / hexane; ethanol

5.1: trimethoxonium tetrafluoroborate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

5.2: 48 h / 20 °C

With N-Bromosuccinimide; water; trimethoxonium tetrafluoroborate; sodium hydride; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide;