N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea

Base Information

• Chemical Name: N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea
• CAS No.: 344436-12-0
• Molecular Formula: C₂₅H₂₇N₃O
• Molecular Weight: 385.509
• Mol file: 344436-12-0.mol

Synonyms:N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea

Chemical Property of N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea

There total 1 articles about N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-amino-1-benzylpiperidine (50541-93-0) + [1,1'-biphenyl]-2-yl-isocyanate (17337-13-2) → N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea (344436-12-0)

Guidance literature:

In acetonitrile; at 0 - 35 ℃; for 12.33h; Product distribution / selectivity;

Reference yield:

N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea (344436-12-0) → C45H53N5O4

Guidance literature:

Multi-step reaction with 6 steps

1: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

3: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4: sodium tris(acetoxy)borohydride / methanol; dichloromethane

5: 20 % Pd(OH)2/C; hydrogen / ethanol

6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

N-1,1'-biphenyl-2-yl-N'-4-(1-benzyl)piperidinylurea (344436-12-0) → 1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea (743460-09-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

3: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4: sodium tris(acetoxy)borohydride / methanol; dichloromethane

5: 20 % Pd(OH)2/C; hydrogen / ethanol

6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

7: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.043

upstream raw materials:

4-amino-1-benzylpiperidine

[1,1'-biphenyl]-2-yl-isocyanate

Downstream raw materials:

1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

C₄₁H₅₂N₄O

C₄₂H₆₂N₄O₅Si

biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-(3-formylamino-4-hydroxy-phenyl)-2-hydroxyethylamino]nonyl}piperidin-4-yl ester