2-Hydroxyethyl oleanolate

Base Information

• Chemical Name: 2-Hydroxyethyl oleanolate
• CAS No.: 892869-48-6
• Molecular Formula: C₃₂H₅₂O₄
• Molecular Weight: 500.762
• Mol file: 892869-48-6.mol

Synonyms:2-Hydroxyethyl oleanolate;(3β)-3-Hydroxy-olean-12-en-28-oic acid 2-hydroxyethyl ester;2-Hydroxyethyl (3beta)-3-hydroxyolean-12-en-28-oate;(3beta)-3-Hydroxy-olean-12-en-28-oic acid 2-hydroxyethyl ester

Chemical Property of 2-Hydroxyethyl oleanolate

Chemical Property:

• PSA: 66.76000
• LogP: 6.68450

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxyethyl oleanolate

There total 3 articles about 2-Hydroxyethyl oleanolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Oleanolic acid (508-02-1) + 2-bromoethanol (540-51-2) → 2-hydroxyethyl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate (892869-48-6)

Guidance literature:

Oleanolic acid; With potassium carbonate; In N,N-dimethyl-formamide; for 6h;

2-bromoethanol; In N,N-dimethyl-formamide; at 23 - 27 ℃; for 8h;

DOI:10.1002/cbdv.202100831

Reference yield: 78.0%

2-bromoethyl 3β-hydroxyolean-12-en-28-oate (875753-08-5) → 2-hydroxyethyl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate (892869-48-6)

Guidance literature:

With ethanol; triethylamine; Heating;

DOI:10.1016/j.bmcl.2006.03.009

Reference yield:

Oleanolic acid (508-02-1) → 2-hydroxyethyl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate (892869-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 40 °C

2: 78 percent / aq. EtOH; Et₃N / Heating

With ethanol; potassium carbonate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.03.009

upstream raw materials:

2-bromoethyl 3β-hydroxyolean-12-en-28-oate

Oleanolic acid

2-bromoethanol