trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Base Information

Chemical Name:trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine
CAS No.:1400872-83-4
Molecular Formula:C₂₁H₂₃N₉
Molecular Weight:401.474
Hs Code.:

Synonyms:trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Suppliers and Price of trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

There total 7 articles about trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 109-09-1
2-chloropyridine

: 1330596-44-5
tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

: 1400872-83-4
trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: 2-chloropyridine; tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate; With potassium tert-butylate; palladium diacetate; In 1,2-dimethoxyethane; at 80 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; methanol; for 0.666667h;

Reference yield: 6.0%

: C₂₆H₃₁N₉O₂

: 1400872-83-4
trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; water; for 0.666667h;
DOI:10.1021/jm500342d

Reference yield:

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1400872-83-4
trans-N-{3-[2-(pyridin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 30 h / 180 °C / microwave irradiation

2.1: dmap; triethylamine / tetrahydrofuran / 18 h / Reflux

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

4.1: potassium tert-butylate / palladium diacetate / 1,2-dimethoxyethane / 3 h / 80 °C

4.2: 0.67 h

With dmap; potassium tert-butylate; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;