Technology Process of C21H25BrF3N3O2
There total 6 articles about C21H25BrF3N3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 0.166667h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water; toluene / 0.33 h / 1 - 10 °C
1.2: 12 - 15 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -77 - -62 °C
2.2: 1.17 h / -76.3 - -63.2 °C
2.3: pH 1
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 6 h / 80 °C
4.1: N-Bromosuccinimide / chloroform / 0.17 h
5.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C
With
sodium hydroxide; N-Bromosuccinimide; n-butyllithium; sodium hydride; sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; hexane; chloroform; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 6 h / 80 °C
2: N-Bromosuccinimide / chloroform / 0.17 h
3: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C
With
N-Bromosuccinimide; sodium hydride; sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; chloroform; water;