3-ETHYLPHENYLBORONIC ACID

Base Information

• Chemical Name: 3-ETHYLPHENYLBORONIC ACID
• CAS No.: 90555-65-0
• Molecular Formula: C8H11 B O2
• Molecular Weight: 149.985
• Hs Code.: 2931900090
• Mol file: 90555-65-0.mol

Synonyms:Benzeneboronicacid, m-ethyl- (7CI); Boronic acid, (3-ethylphenyl)- (9CI);3-Ethylphenylboronic acid

Chemical Property of 3-ETHYLPHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 102.5-107.5 C
• Boiling Point: 299.6°Cat760mmHg
• Flash Point: 135°C
• PSA: 40.46000
• Density: 1.07g/cm³
• LogP: -0.07120
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% min ^*data from raw suppliers

3-Ethylphenylboronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ETHYLPHENYLBORONIC ACID

There total 4 articles about 3-ETHYLPHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-bromo-3-ethylbenzene (2725-82-8) → 3-ethylphenylboronic acid (90555-65-0)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo991853g

Reference yield: 24.0%

n-butyllithium (109-72-8,29786-93-4) + Trimethyl borate (121-43-7,63156-11-6) + 1-bromo-3-ethylbenzene (2725-82-8) → 3-ethylphenylboronic acid (90555-65-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; hexane;

Reference yield:

1,3-dibromobenzene (108-36-1) → 3-ethylphenylboronic acid (90555-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2: 84 percent / n-BuLi; B(O-i-Pr)3 / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; 1: Substitution / 2: Substitution;

DOI:10.1021/jo991853g

upstream raw materials:

1-bromo-3-ethylbenzene

1,3-dibromobenzene

n-butyllithium

Trimethyl borate

Downstream raw materials:

4-(3-ethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

4-(3-ethyl-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl chloride

2-bromo-4-chloro-3-(3-ethylphenyl)pyridine

1-[2-(3-ethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one

Refernces

• 1、 -. "Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors". . . Retrieved 2008/06/13.